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Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

BACKGROUND: Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist antibodies, termed Tri-mAb, consisting of anti-DR5, anti-CD40 and anti-CD137 has...

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Detalles Bibliográficos
Autores principales:	Westwood, Jennifer A, Darcy, Phillip K, Guru, Preethi Mayura, Sharkey, Janelle, Pegram, Hollie J, Amos, Sally M, Smyth, Mark J, Kershaw, Michael H
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873376/ https://www.ncbi.nlm.nih.gov/pubmed/20426873 http://dx.doi.org/10.1186/1479-5876-8-42

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