HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

BACKGROUND: Because some of heat shock protein 90's (HSP90) clients are key cell cycle regulators, HSP90 inhibition can affect the cell cycle. Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a potential anti-tumor agent. However, this agent's effects on the cell...

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Detalles Bibliográficos
Autores principales: Peng, Bin, Xu, Limin, Cao, Fanfan, Wei, Tingxuan, Yang, Chunxin, Uzan, Georges, Zhang, Denghai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873437/
https://www.ncbi.nlm.nih.gov/pubmed/20398364
http://dx.doi.org/10.1186/1476-4598-9-79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873437/
https://www.ncbi.nlm.nih.gov/pubmed/20398364
http://dx.doi.org/10.1186/1476-4598-9-79

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