Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BACKGROUND: Prostaglandin E(2 )(PGE(2)) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα) induces PGE(2 )synthesis in gingival fib...

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Detalles Bibliográficos
Autores principales: Båge, Tove, Lindberg, Johan, Lundeberg, Joakim, Modéer, Thomas, Yucel-Lindberg, Tülay
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873473/
https://www.ncbi.nlm.nih.gov/pubmed/20398340
http://dx.doi.org/10.1186/1471-2164-11-241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873473/
https://www.ncbi.nlm.nih.gov/pubmed/20398340
http://dx.doi.org/10.1186/1471-2164-11-241

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