Optimization algorithms for functional deimmunization of therapeutic proteins

BACKGROUND: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived...

Descripción completa

Detalles Bibliográficos
Autores principales: Parker, Andrew S, Zheng, Wei, Griswold, Karl E, Bailey-Kellogg, Chris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Methodology article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873530/
https://www.ncbi.nlm.nih.gov/pubmed/20380721
http://dx.doi.org/10.1186/1471-2105-11-180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873530/
https://www.ncbi.nlm.nih.gov/pubmed/20380721
http://dx.doi.org/10.1186/1471-2105-11-180

Ejemplares similares