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Optimization algorithms for functional deimmunization of therapeutic proteins

BACKGROUND: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived...

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Detalles Bibliográficos
Autores principales:	Parker, Andrew S, Zheng, Wei, Griswold, Karl E, Bailey-Kellogg, Chris
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Methodology article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873530/ https://www.ncbi.nlm.nih.gov/pubmed/20380721 http://dx.doi.org/10.1186/1471-2105-11-180

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