Cargando…
Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
BACKGROUND: Parkinson's disease (PD) is the most common movement disorder. While neuronal deposition of α-synuclein serves as a pathological hallmark of PD and Dementia with Lewy Bodies, α-synuclein-positive protein aggregates are also present in astrocytes. The pathological consequence of astr...
Autores principales: | Gu, Xing-Long, Long, Cai-Xia, Sun, Lixin, Xie, Chengsong, Lin, Xian, Cai, Huaibin |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873589/ https://www.ncbi.nlm.nih.gov/pubmed/20409326 http://dx.doi.org/10.1186/1756-6606-3-12 |
Ejemplares similares
-
Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice
por: Chen, Xi, et al.
Publicado: (2015) -
No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models
por: Sastry, Namratha, et al.
Publicado: (2015) -
Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice
por: Yu, Jia, et al.
Publicado: (2018) -
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
por: Wang, Pan, et al.
Publicado: (2023) -
Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model
por: Flores-Cuadrado, Alicia, et al.
Publicado: (2019)