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Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4
Bromodomain-containing protein 4 (Brd4) contains two tandem bromodomains (BD1 and BD2) that bind preferentially to acetylated lysine residues found in histones and nonhistone proteins. This molecular recognition allows Brd4 to associate with acetylated chromatin throughout the cell cycle and regulat...
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| Formato: | Texto |
| Lenguaje: | English |
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Biology Reports
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873783/ https://www.ncbi.nlm.nih.gov/pubmed/20495683 http://dx.doi.org/10.3410/B1-98 |