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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil
Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium channel through the activation of protein kinase G (PKG). The purpose of this study was to...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society of Veterinary Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873808/ https://www.ncbi.nlm.nih.gov/pubmed/20458149 http://dx.doi.org/10.4142/jvs.2010.11.2.103 |