Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A(1 )receptor activation

BACKGROUND: Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, migh...

Descripción completa

Detalles Bibliográficos
Autores principales: Sowa, Nathaniel A, Voss, Meagen K, Zylka, Mark J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874211/
https://www.ncbi.nlm.nih.gov/pubmed/20398264
http://dx.doi.org/10.1186/1744-8069-6-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874211/
https://www.ncbi.nlm.nih.gov/pubmed/20398264
http://dx.doi.org/10.1186/1744-8069-6-20

Ejemplares similares