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A short and efficient synthesis of valsartan via a Negishi reaction
An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan(®)) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes many of the drawbacks associated with prev...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874312/ https://www.ncbi.nlm.nih.gov/pubmed/20502651 http://dx.doi.org/10.3762/bjoc.6.27 |