Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells

OBJECTIVE: Multiple type 1 diabetes susceptibility genes have now been identified in both humans and mice, yet mechanistic understanding of how they impact disease pathogenesis is still minimal. We have sought to dissect the cellular basis for how the highly protective mouse Idd9 region limits the e...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S., Sherman, Linda A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874709/
https://www.ncbi.nlm.nih.gov/pubmed/20299469
http://dx.doi.org/10.2337/db09-1801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874709/
https://www.ncbi.nlm.nih.gov/pubmed/20299469
http://dx.doi.org/10.2337/db09-1801

Ejemplares similares