Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

OBJECTIVE: Oxidative stress is a key pathogenic factor in diabetic retinopathy. We previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice. The purpose of this study is to determine the mechanisms underlying the salutary effects of lovastatin in diabetic retin...

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Detalles Bibliográficos
Autores principales: Li, Jingming, Wang, Joshua J., Yu, Qiang, Chen, Kai, Mahadev, Kalyankar, Zhang, Sarah X.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874715/
https://www.ncbi.nlm.nih.gov/pubmed/20332345
http://dx.doi.org/10.2337/db09-1057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874715/
https://www.ncbi.nlm.nih.gov/pubmed/20332345
http://dx.doi.org/10.2337/db09-1057

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