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Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

OBJECTIVE: Oxidative stress is a key pathogenic factor in diabetic retinopathy. We previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice. The purpose of this study is to determine the mechanisms underlying the salutary effects of lovastatin in diabetic retin...

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Detalles Bibliográficos
Autores principales:	Li, Jingming, Wang, Joshua J., Yu, Qiang, Chen, Kai, Mahadev, Kalyankar, Zhang, Sarah X.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874715/ https://www.ncbi.nlm.nih.gov/pubmed/20332345 http://dx.doi.org/10.2337/db09-1057

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