Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

BACKGROUND: The activation of signal transducer and activator of transcription 3 (Stat3) pathway correlates with tumor growth, survival, drug resistance and poor prognosis in osteosarcoma. To explore the potential therapeutic values of this pathway, we assessed both the expression and the activation...

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Detalles Bibliográficos
Autores principales: Ryu, Keinosuke, Susa, Michiro, Choy, Edwin, Yang, Cao, Hornicek, Francis J, Mankin, Henry J, Duan, Zhenfeng
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874784/
https://www.ncbi.nlm.nih.gov/pubmed/20459702
http://dx.doi.org/10.1186/1471-2407-10-187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874784/
https://www.ncbi.nlm.nih.gov/pubmed/20459702
http://dx.doi.org/10.1186/1471-2407-10-187

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