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APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
BACKGROUND: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understanding the function of proteins and studying their interactions. Experimental hot spots detection methods such as alanine scan...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874803/ https://www.ncbi.nlm.nih.gov/pubmed/20377884 http://dx.doi.org/10.1186/1471-2105-11-174 |