Characterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative binding

An approach for enhancing antibody affinity is to engineer Chelating Recombinant Antibodies (CRAbs) which consist of two tandemly linked single-chain Fvs (scFvs) that bind to distinct non-overlapping epitopes on the antigen molecule leading to a synergistic decrease in K(D). In order to develop this...

Descripción completa

Detalles Bibliográficos
Autores principales: Scott, Nathan, Qazi, Omar, Wright, Michael J., Fairweather, Neil F., Deonarain, Mahendra P.
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874839/
https://www.ncbi.nlm.nih.gov/pubmed/20413159
http://dx.doi.org/10.1016/j.molimm.2010.02.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874839/
https://www.ncbi.nlm.nih.gov/pubmed/20413159
http://dx.doi.org/10.1016/j.molimm.2010.02.020

Ejemplares similares