Cargando…
Characterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative binding
An approach for enhancing antibody affinity is to engineer Chelating Recombinant Antibodies (CRAbs) which consist of two tandemly linked single-chain Fvs (scFvs) that bind to distinct non-overlapping epitopes on the antigen molecule leading to a synergistic decrease in K(D). In order to develop this...
| Autores principales: | , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874839/ https://www.ncbi.nlm.nih.gov/pubmed/20413159 http://dx.doi.org/10.1016/j.molimm.2010.02.020 |