Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor

The mechanism behind the positive action of introns upon transcription and the biological significance of this positive feedback remains unclear. Functional ablation of splice sites within an HIV-derived env cDNA significantly reduced transcription that was rescued by a U1 snRNA modified to bind to...

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Detalles Bibliográficos
Autores principales: Alexander, Marina R., Wheatley, Adam K., Center, Rob J., Purcell, Damian F. J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875018/
https://www.ncbi.nlm.nih.gov/pubmed/20071748
http://dx.doi.org/10.1093/nar/gkp1224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875018/
https://www.ncbi.nlm.nih.gov/pubmed/20071748
http://dx.doi.org/10.1093/nar/gkp1224

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