Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction

BACKGROUND: Formation of site specific genomic double strand breaks (DSBs), induced by the expression of a pair of engineered zinc-finger nucleases (ZFNs), dramatically increases the rates of homologous recombination (HR) between a specific genomic target and a donor plasmid. However, for the safe u...

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Detalles Bibliográficos
Autores principales: Olsen, Petter A, Gelazauskaite, Monika, Randøl, Markus, Krauss, Stefan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875229/
https://www.ncbi.nlm.nih.gov/pubmed/20459736
http://dx.doi.org/10.1186/1471-2199-11-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875229/
https://www.ncbi.nlm.nih.gov/pubmed/20459736
http://dx.doi.org/10.1186/1471-2199-11-35

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