A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis

INTRODUCTION: The Rho family GTPase Rac1 regulates cytoskeletal rearrangements crucial for the recruitment, extravasation and activation of leukocytes at sites of inflammation. Rac1 signaling also promotes the activation and survival of lymphocytes and osteoclasts. Therefore, we assessed the ability...

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Detalles Bibliográficos
Autores principales: Abreu, Joana RF, Dontje, Wendy, Krausz, Sarah, de Launay, Daphne, van Hennik, Paula B, van Stalborch, Anne-Marieke, ten Klooster, Jean-Paul, Sanders, Marjolein E, Reedquist, Kris A, Vervoordeldonk, Margriet J, Hordijk, Peter L, Tak, Paul P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875627/
https://www.ncbi.nlm.nih.gov/pubmed/20053277
http://dx.doi.org/10.1186/ar2900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875627/
https://www.ncbi.nlm.nih.gov/pubmed/20053277
http://dx.doi.org/10.1186/ar2900

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