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Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
INTRODUCTION: Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of Ob u...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875652/ https://www.ncbi.nlm.nih.gov/pubmed/20141628 http://dx.doi.org/10.1186/ar2925 |