Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression

INTRODUCTION: Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of Ob u...

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Detalles Bibliográficos
Autores principales: Mutabaruka, Marie-Solange, Aoulad Aissa, Mohamed, Delalandre, Aline, Lavigne, Martin, Lajeunesse, Daniel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875652/
https://www.ncbi.nlm.nih.gov/pubmed/20141628
http://dx.doi.org/10.1186/ar2925

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