The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which ma...

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Autores principales: Willcocks, Lisa C, Lyons, Paul A, Rees, Andrew J, Smith, Kenneth GC
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875655/
https://www.ncbi.nlm.nih.gov/pubmed/20236493
http://dx.doi.org/10.1186/ar2928
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author Willcocks, Lisa C
Lyons, Paul A
Rees, Andrew J
Smith, Kenneth GC
author_facet Willcocks, Lisa C
Lyons, Paul A
Rees, Andrew J
Smith, Kenneth GC
author_sort Willcocks, Lisa C
collection PubMed
description The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
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spelling pubmed-28756552010-08-15 The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis Willcocks, Lisa C Lyons, Paul A Rees, Andrew J Smith, Kenneth GC Arthritis Res Ther Review The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals. BioMed Central 2010 2010-02-15 /pmc/articles/PMC2875655/ /pubmed/20236493 http://dx.doi.org/10.1186/ar2928 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Willcocks, Lisa C
Lyons, Paul A
Rees, Andrew J
Smith, Kenneth GC
The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title_full The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title_fullStr The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title_full_unstemmed The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title_short The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
title_sort contribution of genetic variation and infection to the pathogenesis of anca-associated systemic vasculitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875655/
https://www.ncbi.nlm.nih.gov/pubmed/20236493
http://dx.doi.org/10.1186/ar2928
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