Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage

INTRODUCTION: Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. Apoptosis resistance seems to involve defects in the extrinsic and intrinsic...

Descripción completa

Detalles Bibliográficos
Autores principales: García, Samuel, Liz, Myriam, Gómez-Reino, Juan J, Conde, Carmen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875667/
https://www.ncbi.nlm.nih.gov/pubmed/20187936
http://dx.doi.org/10.1186/ar2941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875667/
https://www.ncbi.nlm.nih.gov/pubmed/20187936
http://dx.doi.org/10.1186/ar2941

Ejemplares similares