An Active Form of Sphingosine Kinase-1 Is Released in the Extracellular Medium as Component of Membrane Vesicles Shed by Two Human Tumor Cell Lines

Expression of sphingosine kinase-1 (SphK-1) correlates with a poor survival rate of tumor patients. This effect is probably due to the ability of SphK-1 to be released into the extracellular medium where it catalyzes the biosynthesis of sphingosine-1-phosphate (S1P), a signaling molecule endowed wit...

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Detalles Bibliográficos
Autores principales: Rigogliuso, Salvatrice, Donati, Chiara, Cassarà, Donata, Taverna, Simona, Salamone, Monica, Bruni, Paola, Vittorelli, Maria Letizia
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875746/
https://www.ncbi.nlm.nih.gov/pubmed/20508814
http://dx.doi.org/10.1155/2010/509329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875746/
https://www.ncbi.nlm.nih.gov/pubmed/20508814
http://dx.doi.org/10.1155/2010/509329

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