Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments

Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates. The major isoforms are determined by alternative mRNA splicing of exon 10 generating tau with three (3R) or four (4R) ∼32 amin...

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Detalles Bibliográficos
Autores principales: Adams, Stephanie J., DeTure, Michael A., McBride, Melinda, Dickson, Dennis W., Petrucelli, Leonard
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876030/
https://www.ncbi.nlm.nih.gov/pubmed/20520830
http://dx.doi.org/10.1371/journal.pone.0010810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876030/
https://www.ncbi.nlm.nih.gov/pubmed/20520830
http://dx.doi.org/10.1371/journal.pone.0010810

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