Differential sensitivity of melanoma cell lines with BRAF(V600E )mutation to the specific Raf inhibitor PLX4032

Blocking oncogenic signaling induced by the BRAF(V600E )mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 decreased signaling through the MAPK pathway only in cell...

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Detalles Bibliográficos
Autores principales: Søndergaard, Jonas N, Nazarian, Ramin, Wang, Qi, Guo, Deliang, Hsueh, Teli, Mok, Stephen, Sazegar, Hooman, MacConaill, Laura E, Barretina, Jordi G, Kehoe, Sarah M, Attar, Narsis, von Euw, Erika, Zuckerman, Jonathan E, Chmielowski, Bartosz, Comin-Anduix, Begoña, Koya, Richard C, Mischel, Paul S, Lo, Roger S, Ribas, Antoni
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876068/
https://www.ncbi.nlm.nih.gov/pubmed/20406486
http://dx.doi.org/10.1186/1479-5876-8-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876068/
https://www.ncbi.nlm.nih.gov/pubmed/20406486
http://dx.doi.org/10.1186/1479-5876-8-39

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