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Fine-tuning structural RNA alignments in the twilight zone
BACKGROUND: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score based on thermodynamics and covariance. This method works best around 75% sequence similarity. However, in a "twilig...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876130/ https://www.ncbi.nlm.nih.gov/pubmed/20433706 http://dx.doi.org/10.1186/1471-2105-11-222 |