Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

The type 5 G protein β subunit (Gβ5) can form complexes with members of the Regulator of G protein Signaling 7 (RGS7) family, but the relevance to neuronal G protein signaling is unclear. We report that mouse RGS7/Gβ5 complexes bind to G protein–gated potassium channels and facilitate their function...

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Detalles Bibliográficos
Autores principales: Xie, Keqiang, Allen, Kevin L., Kourrich, Saïd, Colón–Saez, José, Thomas, Mark J., Wickman, Kevin, Martemyanov, Kirill A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876203/
https://www.ncbi.nlm.nih.gov/pubmed/20453851
http://dx.doi.org/10.1038/nn.2549
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author Xie, Keqiang
Allen, Kevin L.
Kourrich, Saïd
Colón–Saez, José
Thomas, Mark J.
Wickman, Kevin
Martemyanov, Kirill A.
author_facet Xie, Keqiang
Allen, Kevin L.
Kourrich, Saïd
Colón–Saez, José
Thomas, Mark J.
Wickman, Kevin
Martemyanov, Kirill A.
author_sort Xie, Keqiang
collection PubMed
description The type 5 G protein β subunit (Gβ5) can form complexes with members of the Regulator of G protein Signaling 7 (RGS7) family, but the relevance to neuronal G protein signaling is unclear. We report that mouse RGS7/Gβ5 complexes bind to G protein–gated potassium channels and facilitate their functional coupling to GABA(B) receptors in neurons. These findings identify a novel compartmentalization mechanism critical for ensuring high temporal resolution of neuronal G protein signaling.
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spelling pubmed-28762032010-12-01 Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling Xie, Keqiang Allen, Kevin L. Kourrich, Saïd Colón–Saez, José Thomas, Mark J. Wickman, Kevin Martemyanov, Kirill A. Nat Neurosci Article The type 5 G protein β subunit (Gβ5) can form complexes with members of the Regulator of G protein Signaling 7 (RGS7) family, but the relevance to neuronal G protein signaling is unclear. We report that mouse RGS7/Gβ5 complexes bind to G protein–gated potassium channels and facilitate their functional coupling to GABA(B) receptors in neurons. These findings identify a novel compartmentalization mechanism critical for ensuring high temporal resolution of neuronal G protein signaling. 2010-05-09 2010-06 /pmc/articles/PMC2876203/ /pubmed/20453851 http://dx.doi.org/10.1038/nn.2549 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Xie, Keqiang
Allen, Kevin L.
Kourrich, Saïd
Colón–Saez, José
Thomas, Mark J.
Wickman, Kevin
Martemyanov, Kirill A.
Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title_full Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title_fullStr Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title_full_unstemmed Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title_short Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
title_sort gβ5 recruits r7 rgs proteins to girk channels to regulate the timing of neuronal inhibitory signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876203/
https://www.ncbi.nlm.nih.gov/pubmed/20453851
http://dx.doi.org/10.1038/nn.2549
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