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Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma
Scleroderma (systemic sclerosis, SSc) is a fibrotic disease for which there is no therapy. CCN2 (connective tissue growth factor, CTGF) is a marker and mediator of fibrosis. Previously, it has been shown that thrombin induces CCN2 expression in fibroblasts. In a recent fascinating report, Bogatkevic...
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| Formato: | Texto |
| Lenguaje: | English |
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Springer Netherlands
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876241/ https://www.ncbi.nlm.nih.gov/pubmed/19957054 http://dx.doi.org/10.1007/s12079-009-0082-2 |