T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease

Patients with Alzheimer's disease (AD) exhibit substantial accumulation of amyloid-β (Aβ) plaques in the brain. Here, we examine whether Aβ vaccination can facilitate the migration of T lymphocytes to specifically target Aβ plaques and consequently enhance their removal. Using a new mouse model...

Descripción completa

Detalles Bibliográficos
Autores principales: Fisher, Yair, Nemirovsky, Anna, Baron, Rona, Monsonego, Alon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877087/
https://www.ncbi.nlm.nih.gov/pubmed/20520819
http://dx.doi.org/10.1371/journal.pone.0010830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877087/
https://www.ncbi.nlm.nih.gov/pubmed/20520819
http://dx.doi.org/10.1371/journal.pone.0010830

Ejemplares similares