A Chemical Genetic Screen for Modulators of Asymmetrical 2,2′-Dimeric Naphthoquinones Cytotoxicity in Yeast

BACKGROUND: Dimeric naphthoquinones (BiQ) were originally synthesized as a new class of HIV integrase inhibitors but have shown integrase-independent cytotoxicity in acute lymphoblastic leukemia cell lines suggesting their use as potential anti-neoplastic agents. The mechanism of this cytotoxicity i...

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Detalles Bibliográficos
Autores principales: Emadi, Ashkan, Ross, Ashley E., Cowan, Kathleen M., Fortenberry, Yolanda M., Vuica-Ross, Milena
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877097/
https://www.ncbi.nlm.nih.gov/pubmed/20520766
http://dx.doi.org/10.1371/journal.pone.0010846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877097/
https://www.ncbi.nlm.nih.gov/pubmed/20520766
http://dx.doi.org/10.1371/journal.pone.0010846

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