Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma

BACKGROUND: Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma. METHODOLOGY/PRINCIPAL FINDINGS: We crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mic...

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Detalles Bibliográficos
Autores principales: Castellino, Robert C., Barwick, Benjamin G., Schniederjan, Matthew, Buss, Meghan C., Becher, Oren, Hambardzumyan, Dolores, MacDonald, Tobey J., Brat, Daniel J., Durden, Donald L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877103/
https://www.ncbi.nlm.nih.gov/pubmed/20520772
http://dx.doi.org/10.1371/journal.pone.0010849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877103/
https://www.ncbi.nlm.nih.gov/pubmed/20520772
http://dx.doi.org/10.1371/journal.pone.0010849

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