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Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma
BACKGROUND: Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma. METHODOLOGY/PRINCIPAL FINDINGS: We crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mic...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877103/ https://www.ncbi.nlm.nih.gov/pubmed/20520772 http://dx.doi.org/10.1371/journal.pone.0010849 |