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Orm family proteins mediate sphingolipid homeostasis
Despite the essential roles of sphingolipids as both structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels. Here we reveal the function in sphingolipid metabolism of the ORM/ORMDL genes, a conserved gene fam...
Autores principales: | Breslow, David K., Collins, Sean R., Bodenmiller, Bernd, Aebersold, Ruedi, Simons, Kai, Shevchenko, Andrej, Ejsing, Christer S., Weissman, Jonathan S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877384/ https://www.ncbi.nlm.nih.gov/pubmed/20182505 http://dx.doi.org/10.1038/nature08787 |
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