α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs

Toxicity of human α-synuclein when expressed in simple organisms can be suppressed by overexpression of endoplasmic reticulum (ER)-to-Golgi transport machinery, suggesting that inhibition of constitutive secretion represents a fundamental cause of the toxicity. Whether similar inhibition in mammals...

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Detalles Bibliográficos
Autores principales: Thayanidhi, Nandhakumar, Helm, Jared R., Nycz, Deborah C., Bentley, Marvin, Liang, Yingjian, Hay, Jesse C.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877643/
https://www.ncbi.nlm.nih.gov/pubmed/20392839
http://dx.doi.org/10.1091/mbc.E09-09-0801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877643/
https://www.ncbi.nlm.nih.gov/pubmed/20392839
http://dx.doi.org/10.1091/mbc.E09-09-0801

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