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Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats

BACKGROUND: Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreventive agents. Genetic mutations relevant to human colon cancer have been describ...

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Detalles Bibliográficos
Autores principales: Femia, Angelo Pietro, Luceri, Cristina, Toti, Simona, Giannini, Augusto, Dolara, Piero, Caderni, Giovanna
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877689/
https://www.ncbi.nlm.nih.gov/pubmed/20459814
http://dx.doi.org/10.1186/1471-2407-10-194