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Calmodulin Interaction with hEAG1 Visualized by FRET Microscopy

BACKGROUND: Ca(2+)-mediated regulation of ion channels provides a link between intracellular signaling pathways and membrane electrical activity. Intracellular Ca(2+) inhibits the voltage-gated potassium channel EAG1 through the direct binding of calmodulin (CaM). Three CaM binding sites (BD-C1: 674...

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Detalles Bibliográficos
Autores principales: Gonçalves, J. Tiago, Stühmer, Walter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877719/
https://www.ncbi.nlm.nih.gov/pubmed/20523736
http://dx.doi.org/10.1371/journal.pone.0010873