Massive APOBEC3 Editing of Hepatitis B Viral DNA in Cirrhosis

DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV), are vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine deaminases. At least three A3 genes are up regulated by interferon-α in human hepatocytes while ectopic expression of activation...

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Detalles Bibliográficos
Autores principales: Vartanian, Jean-Pierre, Henry, Michel, Marchio, Agnès, Suspène, Rodolphe, Aynaud, Marie-Ming, Guétard, Denise, Cervantes-Gonzalez, Minerva, Battiston, Carlo, Mazzaferro, Vincenzo, Pineau, Pascal, Dejean, Anne, Wain-Hobson, Simon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877740/
https://www.ncbi.nlm.nih.gov/pubmed/20523896
http://dx.doi.org/10.1371/journal.ppat.1000928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877740/
https://www.ncbi.nlm.nih.gov/pubmed/20523896
http://dx.doi.org/10.1371/journal.ppat.1000928

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