The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning

Numerous studies show that pharmacological inhibition of p38 mitogen-activated protein kinases (p38s) before lethal ischemia prevents conditioning. However, these inhibitors have off-target effects and do not discriminate between the alpha and beta isoforms; the activation of which is thought to hav...

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Detalles Bibliográficos
Autores principales: Sicard, Pierre, Clark, James E., Jacquet, Sebastien, Mohammadi, Shahrooz, Arthur, J. Simon C., O'Keefe, Stephen J., Marber, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877771/
https://www.ncbi.nlm.nih.gov/pubmed/20188737
http://dx.doi.org/10.1016/j.yjmcc.2010.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877771/
https://www.ncbi.nlm.nih.gov/pubmed/20188737
http://dx.doi.org/10.1016/j.yjmcc.2010.02.013

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