Cargando…
The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
Numerous studies show that pharmacological inhibition of p38 mitogen-activated protein kinases (p38s) before lethal ischemia prevents conditioning. However, these inhibitors have off-target effects and do not discriminate between the alpha and beta isoforms; the activation of which is thought to hav...
Autores principales: | Sicard, Pierre, Clark, James E., Jacquet, Sebastien, Mohammadi, Shahrooz, Arthur, J. Simon C., O'Keefe, Stephen J., Marber, Michael S. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877771/ https://www.ncbi.nlm.nih.gov/pubmed/20188737 http://dx.doi.org/10.1016/j.yjmcc.2010.02.013 |
Ejemplares similares
-
The case for inhibiting p38 mitogen-activated protein kinase in heart failure
por: Arabacilar, Pelin, et al.
Publicado: (2015) -
Mechanism and consequence of the autoactivation p38α Mitogen-activated Protein Kinase promoted by TAB1
por: DeNicola, Gian Felice, et al.
Publicado: (2013) -
Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
por: Bassi, Rekha, et al.
Publicado: (2017) -
P38 Mitogen-activated Protein Kinase and Parkinson’s Disease
por: He, Jianying, et al.
Publicado: (2018) -
Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease
por: Kitatani, Kazuyuki, et al.
Publicado: (2015)