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Structural and Functional Analysis of the Engineered Type I DNA Methyltransferase EcoR124I(NT)
The Type I R–M system EcoR124I is encoded by three genes. HsdM is responsible for modification (DNA methylation), HsdS for DNA sequence specificity and HsdR for restriction endonuclease activity. The trimeric methyltransferase (M(2)S) recognises the asymmetric sequence (GAAN(6)RTCG). An engineered R...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877798/ https://www.ncbi.nlm.nih.gov/pubmed/20302878 http://dx.doi.org/10.1016/j.jmb.2010.03.008 |