TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

BACKGROUND: Overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's disease (AD). Therefore, attenuating microglial clustering can reduce focal neuroinflammation at neuritic plaques. Previ...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Chao, Yen, Feng-Chang, Shie, Feng-Shiun, Pan, Chih-Ming, Shiao, Young-Ji, Yang, Cheng-Ning, Huang, Fong-Lee, Sung, Yen-Jen, Tsay, Huey-Jen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878297/
https://www.ncbi.nlm.nih.gov/pubmed/20429874
http://dx.doi.org/10.1186/1742-2094-7-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878297/
https://www.ncbi.nlm.nih.gov/pubmed/20429874
http://dx.doi.org/10.1186/1742-2094-7-28

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