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Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

BACKGROUND: An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating can...

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Detalles Bibliográficos
Autores principales: Alkaitis, Matthew S., Solorzano, Carlos, Landry, Russell P., Piomelli, Daniele, DeLeo, Joyce A., Romero-Sandoval, E. Alfonso
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878341/
https://www.ncbi.nlm.nih.gov/pubmed/20531936
http://dx.doi.org/10.1371/journal.pone.0010891