Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo

α-Synuclein (a-Syn), a protein implicated in Parkinson disease, contributes significantly to dopamine metabolism. a-Syn binding inhibits the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Phosphorylation of TH stimulates its activity, an effect that is re...

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Detalles Bibliográficos
Autores principales: Lou, Haiyan, Montoya, Susana E., Alerte, Tshianda N. M., Wang, Jian, Wu, Jianjun, Peng, Xiangmin, Hong, Chang-Sook, Friedrich, Emily E., Mader, Samantha A., Pedersen, Courtney J., Marcus, Brian S., McCormack, Alison L., Di Monte, Donato A., Daubner, S. Colette, Perez, Ruth G.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878529/
https://www.ncbi.nlm.nih.gov/pubmed/20356833
http://dx.doi.org/10.1074/jbc.M110.100867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878529/
https://www.ncbi.nlm.nih.gov/pubmed/20356833
http://dx.doi.org/10.1074/jbc.M110.100867

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