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Validation of Coevolving Residue Algorithms via Pipeline Sensitivity Analysis: ELSC and OMES and ZNMI, Oh My!

Correlated amino acid substitution algorithms attempt to discover groups of residues that co-fluctuate due to either structural or functional constraints. Although these algorithms could inform both ab initio protein folding calculations and evolutionary studies, their utility for these purposes has...

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Detalles Bibliográficos
Autores principales: Brown, Christopher A., Brown, Kevin S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879359/
https://www.ncbi.nlm.nih.gov/pubmed/20531955
http://dx.doi.org/10.1371/journal.pone.0010779