Aged Tgfβ2/Gdnf double-heterozygous mice show no morphological and functional alterations in the nigrostriatal system

Loss of dopaminergic neurons in the substantia nigra pars compacta and the resulting decrease in striatal dopamine levels are the hallmarks of Parkinson’s disease. Tgfβ and Gdnf have been identified as neurotrophic factors for dopaminergic midbrain neurons in vivo and in vitro. Haploinsufficiency fo...

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Detalles Bibliográficos
Autores principales: Heermann, Stephan, Opazo, Felipe, Falkenburger, Björn, Krieglstein, Kerstin, Spittau, Björn
Formato: Texto
Lenguaje:English
Publicado: Springer Vienna 2010
Materias:
Basic Neurosciences, Genetics and Immunology - Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879483/
https://www.ncbi.nlm.nih.gov/pubmed/20458508
http://dx.doi.org/10.1007/s00702-010-0406-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879483/
https://www.ncbi.nlm.nih.gov/pubmed/20458508
http://dx.doi.org/10.1007/s00702-010-0406-7

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