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Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production
Through the shuffling of predefined modular zinc finger (ZF) domains with predictable target site recognition in vitro, we have generated a large repertoire of artificial transcription factors (ATFs) with five ZF domains (TF(ZF)s). Here we report an effective strategy for the selection of ATF librar...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880176/ https://www.ncbi.nlm.nih.gov/pubmed/19838191 http://dx.doi.org/10.1038/nsmb.1677 |