Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

BACKGROUND: To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of colon cancer is associated with high ages, young patients bearing this type of malignancy are rare and could provide additional insight into...

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Detalles Bibliográficos
Autores principales: van Roon, Eddy HJ, van Puijenbroek, Marjo, Middeldorp, Anneke, van Eijk, Ronald, de Meijer, Emile J, Erasmus, Dianhdra, Wouters, Kim AD, van Engeland, Manon, Oosting, Jan, Hes, Frederik J, Tops, Carli MJ, van Wezel, Tom, Boer, Judith M, Morreau, Hans
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880297/
https://www.ncbi.nlm.nih.gov/pubmed/20444249
http://dx.doi.org/10.1186/1471-2407-10-180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880297/
https://www.ncbi.nlm.nih.gov/pubmed/20444249
http://dx.doi.org/10.1186/1471-2407-10-180

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