Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases

The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we r...

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Detalles Bibliográficos
Autores principales: Apsel, Beth, Blair, Jimmy A., Gonzalez, Beatriz Z., Nazif, Tamim M., Feldman, Morri E., Aizenstein, Brian, Hoffman, Randy, Williams, Roger L., Shokat, Kevan M., Knight, Zachary A.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880455/
https://www.ncbi.nlm.nih.gov/pubmed/18849971
http://dx.doi.org/10.1038/nchembio.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880455/
https://www.ncbi.nlm.nih.gov/pubmed/18849971
http://dx.doi.org/10.1038/nchembio.117

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